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  • Writer's pictureDahlia Foundation

Understanding mechanisms of alcohol-associated bowel disease

Alcohol consumption is a significant risk factor for gastrointestinal diseases, including cancer. Alcohol can damage the gastrointestinal tract in several ways. It can promote an impairment of several intestinal barrier functions, leading to leaky gut and dysbiosis. Ethanol metabolism can also produce toxic substances such as acetaldehyde and acetate, further damaging the gut and potentially promoting cancer.


More research is needed to understand ABD's mechanisms and develop effective treatments. There is some evidence to suggest that ABD may precede or contribute to ALD. For example, approximately 90% of alcohol user disorder (AUD) patients present with mild liver disease. However, most will likely have certain degrees of bowel dysfunctions (e.g., malabsorption, intestinal permeability, immune dysfunctions), suggesting that ABD may precede in certain patients and promote or contribute to ALD.


Future studies are needed to better understand the role of the intestine in ethanol metabolism and the impact of ethanol on the intestine. These studies could help identify new targets for preventing and treating ABD.


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Phone Number : 9833998907


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